During the process of rearrangement, DNA byproducts are generated called T-cell receptor excision circles (TREC) and these are used as markers of T cells that have recently emigrated from the thymus (TRECS / T-Cell Receptor Excision Circles Analysis, Blood). TCR gene rearrangement takes place in the thymus. The rearrangement of the T-cell receptor (TCR) through somatic recombination of V (variable), D (diversity), J (joining), and C (constant) regions is a defining event in the development and maturation of a T cell. Supplies: Ambient Shipping Box-Critical Specimens Only (T668)Ĭollection Instructions: Send whole blood specimen in original tube.
T CELL RECEPTOR REPERTOIRE ANALYSIS SERIAL
Testing will proceed without the form however, results will be held under the information is received.įor serial monitoring, it is recommended to perform specimen collection at the same time of day, if possible. TCR V beta Spectratyping Assay Patient Information (T719) is required. Ordering physician's name and phone number are required. Samples arriving over the weekend and/or on observed holidays may be canceled. It is recommended that specimens arrive within 24 hours of collection. Collect and package specimen as close to shipping time as possible. Specimens must be received in the laboratory on weekdays and by 4 p.m. TCP / T-Cell Subsets, Naive, Memory, and Activated, Blood CD4RT / CD4 T-Cell Recent Thymic Emigrants, Blood TRECS / T-Cell Receptor Excision Circles (TREC) Analysis, Blood Mayo Clinic Laboratory Director/Consultant approval is required prior to ordering this test in patients greater than 40 years of age.Īdditional tests that could be ordered in conjunction with this test include:
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